منابع مشابه
Bringing stability to microtubules
T he removal of a single tyrosine residue from the C terminus of ␣-tubulin dramatically affects microtubules and their depolymerizing motors, say < a d d a r t t y p e = " r e l " d o i = " 1 0. 1 0 8 3 / j c b. 2 0 0 9 0 2 1 4 2 " > Peris et al.< / a d d a r t > ␣-tubulin undergoes a cycle of tyrosine removal and readdition, catalyzed by a carboxypeptidase and tubulin tyrosine ligase (TTL). Mi...
متن کاملStability properties of neuronal microtubules.
Neurons are terminally differentiated cells that use their microtubule arrays not for cell division but rather as architectural elements required for the elaboration of elongated axons and dendrites. In addition to acting as compression-bearing struts that provide for the shape of the neuron, microtubules also act as directional railways for organelle transport. The stability properties of neur...
متن کاملStability of Brain Microtubules in Homogenates
Hexylene glycol buffered at pH 6 .4 (7) will preserve microtubules from mammalian brain in homogenates (9) . The observations presented here show that hexylene glycol is better than ethanol or sucrose for preserving the microtubules ; nevertheless, the concentration of microtubules decreases with time even in the presence of hexylene glycol . Cold, autolysis, divalent cations, and mitotic spind...
متن کاملTau confers drug stability but not cold stability to microtubules in living cells.
We previously defined two classes of microtubule polymer in the axons of cultured sympathetic neurons that differ in their sensitivity to nocodazole by roughly 35-fold (Baas and Black (1990) J. Cell Biol. 111, 495-509). Here we demonstrate that virtually all of the microtubule polymer in these axons, including the drug-labile polymer, is stable to cold. What factors account for the unique stabi...
متن کاملInfluence of taxol and CNTs on the stability analysis of protein microtubules
Microtubules are used as targets for anticancer drugs due to their crucial role in the process of mitosis. Recent studies show that carbon nanotubes (CNTs) can be classified as microtubule-stabilizing agents as they interact with protein microtubules (MTs), leading to interference in the mitosis process. CNTs hold a substantial promising application in cancer therapy in conjunction with other c...
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ژورنال
عنوان ژورنال: Journal of Cell Biology
سال: 2009
ISSN: 1540-8140,0021-9525
DOI: 10.1083/jcb.1857iti1